4 lifestyle changes may improve cognitive function, slow Alzheimer’s, study finds

ISLAMABAD, June 14 (Online): Alzheimer’s disease is a progressive disease that affects thought and functioning and is the most common dementia type.
Researchers have been interested in finding out if there are ways to improve cognitive function among people with Alzheimer’s disease, as there is not yet a cure.
Results from a recent study indicate that certain lifestyle interventions may help improve or prevent the decline of cognitive function in people with mild cognitive impairment or early dementia due to Alzheimer’s disease.
These lifestyle changes include stress management, exercise, and limiting meat consumption, among others.
Receiving a dementia diagnosis can be devastating and discouraging. However, experts are determined to figure out how to best help people with Alzheimer’s disease, and recent research in this area is hopeful.

A recent studyTrusted Source published in Alzheimer’s Research & TherapyTrusted Source examined how intensive lifestyle interventions can help people in the early stages of Alzheimer’s disease.

In a 20-week intervention, researchers found that combining lifestyle interventions like following a plant-based diet, exercising, managing stress, and attending group support meetings may help improve cognitive function.

The results point to potential intervention paths to help people with early dementia or interventions to possibly prevent dementia.

How Alzheimer’s disease affects health
Alzheimer’s diseaseTrusted Source is a condition that results in brain changes and impacts over six million people in the United States alone.

People with Alzheimer’s diseaseTrusted Source often experience a progressive decline in their cognitive function and memory. They may struggle with memory loss, personality changes, and declines in judgment. Alzheimer’s disease is also the most common dementia type, making it a particularly important area for research focus.

Shannel Kassis Elhelou, Psy.D., geropsychology and neuropsychology fellow at Pacific Neuroscience Institute’s Brain Wellness and Lifestyle Programs in Santa Monica, CA, who was not involved in the study, noted the following about Alzheimer’s disease to Medical News Today:

“Alzheimer’s disease significantly impacts quality of life and function through progressive declines in memory, cognitive functioning (attention, processing speed, problem-solving, word finding), tasks of daily living (managing finances, driving, medication management, household duties), as well as changes in mood (increased irritability, anxiety, depression, or apathy).”

“Over time, Alzheimer’s disease leads to declines in physical health, reducing mobility and increasing the risk of falls. Overall, these effects result in social isolation and substantial caregiver burden, further impacting the individual and caregivers’ quality of life,” Elhelou said.

There are medicationsTrusted Source that help people with Alzheimer’s disease, but experts are also interested in how lifestyle interventions can also help. These lifestyle interventions were the focus of the current study.

Which lifestyle changes may prevent Alzheimer’s?
For the current study, researchers wanted to examine if a combination of non-medication interventions could help people in the early stages of Alzheimer’s disease.

This study was a randomized, controlled clinical trial that included fifty-one participants. All participants had mild cognitive impairment or early dementia from Alzheimer’s disease. The average age for participants was 73.5 years. Researchers excluded participants who had moderate or severe dementia and those who could not participate in regular exercise.

Researchers divided participants into two groups. The control group received standard care, and the intervention group received standard care and took part in four key lifestyle interventions:

Implementation of a whole-foods, minimally processed plant-based diet with specific supplements and low levels of harmful fats and refined carbohydrates,
Moderate exercise for at least thirty minutes daily and mild strength training three times a week or more,
Stress management techniques like meditation, yoga, and breathing exercises,
Regular use of support groups three times a week.
Overall, the intervention period lasted 20 weeks, and two participants from the intervention group withdrew. Researchers provided intervention participants with food, assistance with exercise, supervision of stress management techniques, and access to support group meetings.

Researchers used several measurements to assess the success of the interventions, including four assessment tools: the AD assessment Scale—cognitive Subscale, Clinical Global Impression of Change, Clinical Dementia Rating Sum of Boxes, and Clinical Dementia Rating Global. They also examined certain biomarkers and microbiome taxa.

The control group showed declines in all four assessments of cognition and function. In contrast, the intervention group showed improvement in three of the assessments. In the last assessment, the intervention group showed less progression than the control group.

In addition, the intervention group showed improvement in microbiome configuration and improvement in clinically relevant biomarkers compared to controls.

Study author Dean Ornish, founder and president of the nonprofit Preventive Medicine Research Institute and clinical professor of medicine at the University of California, San Francisco, noted the following highlights of the research to Medical News Today:

“What makes our research unique is that it’s the first time a randomized controlled clinical trial has demonstrated that an intensive lifestyle intervention, without drugs, significantly improved cognition and function after 20 weeks in many patients with mild cognitive impairment or early dementia due to Alzheimer’s disease.”

“There was a statistically significant dose-response correlation between the degree of lifestyle changes in both groups and the degree of change in most measures of cognition and function testing. In short, the more these patients changed their lifestyle in the prescribed ways, the greater was the beneficial impact on their cognition and function.”
— Dean Ornish, study author

While the results don’t mean that everyone in the intervention group experienced an improvement in cognition, they do mark superior outcomes to standard care interventions. Ornish noted that “Not all patients in the intervention group improved; in the CGIC test, 71% improved or were unchanged. In contrast, none of the patients in the control group improved, eight were unchanged, and 17 (68%) worsened.”

Should future research confirm these findings, the interventions could see greater emphasis as a way to help people with early Alzheimer’s disease. It may also have implications for Alzheimer’s disease prevention.