ISLAMABAD, JAN 03 (ONLINE): Older adults (aged = 65 years) with diabetes who received insulin may have an increased risk for serious hypoglycemic events in extreme heat.<\/p>\n
METHODOLOGY:
\n\u2022\tThermoregulatory response is often compromised in older adults with diabetes, making them vulnerable to extreme heat.
\n\u2022\tResearchers evaluated the association between ambient heat and risk for hypoglycemia in about 2 million and about 283,000 patients aged 65-100 years with diabetes from the United States and Taiwan, respectively, who received insulin.
\n\u2022\tA serious hypoglycemic event was defined as a primary emergency department (ED) visit or an unplanned inpatient admission for hypoglycemia from June 1 to September 30.
\n\u2022\tMedication use was determined by at least one prescription dispensing insulin within 90 days of the index event.<\/p>\n
\u2022\tThe average heat index (HI), a combination of ambient temperature and humidity exposure, was calculated by zip code and grouped into percentiles: = 99th, 95-98th, 85-94th, 76-84th, 25-74th, and < 25th.\n\nTAKEAWAY:\n\u2022\tAmong insulin users overall, 32,461 and 10,162 older adults from the United States and Taiwan, respectively, experienced a hypoglycemic event.\n\u2022\tThe risk for a serious hypoglycemic event was about 40% higher among insulin users on days with an HI = 99th percentile than 25-74th percentile (unadjusted odds ratio, 1.38; 95% CI, 1.28-1.48).\n\u2022\tConversely, on days with a low HI (< 25th percentile), the risk for hypoglycemia among insulin users decreased.\n\u2022\tNo substantial differences were observed in the risk for hypoglycemic events and HI by climate region in either country, such as between the US Northeast and Southwest.\n\nIN PRACTICE:\n\"Our finding of elevated risk of hypoglycemia-related ED visits in older adults using insulin and exposed to extreme heat underscores the need for patients and providers to be aware and cautious that extreme heat may increase the risk of hypoglycemia,\" the authors wrote.\n\nSOURCE:\nThe study was conducted by first author Aayush Visaria, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey, and coauthors. The study was published online on December 7, 2023 in Diabetes Care.\n\nLIMITATIONS:\n\u2022\tThe individuals with hypoglycemia were older, were more frequently non-Hispanic Black in the United States, and had more comorbidities, so caution should be used before the results can be generalized to broader populations.\n\u2022\tThe authors were unable to capture variables that can alter the risk for serious hypoglycemia, such as outdoor activity, exercise, and diet.\n\u2022\tPrescriptions may not reflect actual insulin use and adherence.\n<\/p>\n","protected":false},"excerpt":{"rendered":"
ISLAMABAD, JAN 03 (ONLINE): Older adults (aged = 65 years) with diabetes who received insulin may have an increased risk for serious hypoglycemic events in extreme heat. METHODOLOGY: \u2022 Thermoregulatory response is often compromised in older adults with diabetes, making them vulnerable to extreme heat. […]<\/p>\n
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