ISLAMABAD\u00a0\u00a0 –\u00a0 A new peer-reviewed study published in the journal Toxicological Research & Application shows acute exposure of a 3D human bronchial tissue model to e-cigarette aerosol has minimal impact on gene expression compared to smoke from combustible cigarettes.The research involved sub-cytotoxic exposure to cells in a 3D human bronchial model (MucilAirTM) to nicotine-containing vape aerosol, combustible cigarette smoke and fresh air control under strict laboratory conditions.The highly sensitive Toxicity Testing in the Twenty-First Century (TT21C)-based technique allows researchers to gain a mechanistic understanding of the potential effects of exposure to vape aerosol and 3R4F (reference cigarette) smoke, without experiencing other processes that may be triggered by significantly higher exposures \u2014 including cell death \u2014 that could potentially make interpretation of results difficult.After cell \u2018recovery\u2019 periods of 4 and 48 hours, scientists assessed the expression of a variety of genes to determine if any were increased or decreased by the single exposure.\u201c<\/p>\n\n\n\n
Within this model, exposure to combustible cigarette smoke triggered significant changes in gene expression, indicating \u2014 amongst other effects \u2014 changes in oxidative stress and inflammation markers,\u201d confirmed Matt Stevenson, Pre-Clinical Toxicology Manager at Imperial Brands.<\/p>\n","protected":false},"excerpt":{"rendered":"
ISLAMABAD\u00a0\u00a0 –\u00a0 A new peer-reviewed study published in the journal Toxicological Research & Application shows acute exposure of a 3D human bronchial tissue model to e-cigarette aerosol has minimal impact on gene expression compared to smoke from combustible cigarettes.The research involved sub-cytotoxic exposure to cells […]<\/p>\n
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