ISLAMABAD, Nov 14 (Online): The link between brain insulin insensitivity and diabetes is well-established, but the exact nature of that connection is still being studied.<\/p>\n
New research from researchers at the German Center for Diabetes Research, T\u00fcbingen University Hospital, and Helmholtz Munich in Munich, Germany, explores the effect of exercise on brain insulin sensitivity.<\/p>\n
The study found that healthy levels of brain insulin sensitivity were restored in participants after an 8-week exercise program.<\/p>\n
The findings were recently published in JCI Insight.<\/p>\n
\u201cThis study reinforces the fact that physical activity is needed to restore the mind-body metabolic pathways in patients with obesity, prediabetes, diabetes, and metabolic disease in general,\u201d Dr. Ana Maria Kausel, an endocrinologist and co-founder of Anzara Health, not involved in the study, told Medical News Today.<\/p>\n
8 weeks of exercise restores insulin sensitivity
\nFor the study, 21 healthy participants with overweight and obesity were enrolled in an 8-week supervised aerobic exercise program.<\/p>\n
The cohort included 14 men and 7 women with a body mass index (BMI) ranging from 27.5 to 45.5 kg\/m2. The participants led sedentary lifestyles and were deemed at risk for developing type 2 diabetes.<\/p>\n
Three times a week, participants were led through 1-hour endurance training sessions. Each session included a combination of cycling and walking to bring individuals up to 80% of their peak oxygen intake, or VO2 max.<\/p>\n
Using functional MRI after administering an insulin nasal spray to each individual, researchers assessed their brain insulin sensitivity at the start of the study and after 8 weeks.<\/p>\n
The exercise program increased insulin action in the brain\u2019s striatum and strengthened functional connections in the hippocampus to levels of people without overweight or obesity.<\/p>\n
The researchers found that improved insulin sensitivity in the brain had positive effects on participants\u2019 metabolism and reduced their sensations of hunger. Participants also decreased their amount of visceral fat, which further benefited their health.<\/p>\n
Ryan Glatt, CPT, NBC-HWC, personal trainer and brain health coach for the Pacific Neuroscience Institute at Providence Saint John\u2019s Health Center in Santa Monica, CA, not involved in the study, noted the following to MNT:<\/p>\n
\u201cThis was an interesting study \u2014 however, the sample size was very small (21 people), with twice as many women as men, which make the study underpowered, especially in the absence of a control group.\u201d<\/p>\n
Diabetes and brain insulin resistance
\nInsulin is a hormone produced by the pancreas that helps the body regulate blood sugar levels.<\/p>\n
In type 1 diabetes, for instance, the immune system attacks cells that produce insulin in the pancreas. In type 2 diabetes, the body becomes resistant to the insulin it produces.<\/p>\n
Although insulin resistance is an element of prediabetes and type 2 diabetes, brain insulin resistance is not quite the same thing.<\/p>\n
\u201cBrain insulin insensitivity can be correlated to diabetes and obesity, but more so has to do with brain metabolism and the efficiency therein,\u201d Glatt explained.<\/p>\n
Dr. Ahmet Ergin, an endocrinologist with SugarMD told MNT agreed, noting that insulin affects brain function.<\/p>\n
\u201cStudies have shown that insulin plays a role in neurotransmission, which means it can influence our mood, behavior, and cognition,\u201d Dr. Ergin said. \u201cOne theory is that brain insulin insensitivity directly causes diabetes by preventing the body from properly processing glucose.\u201d<\/p>\n
\u201cAnother theory suggests that weight gain is the primary driver of diabetes, and that brain insulin insensitivity is indirectly connected to the disease.<\/p>\n
This second theory is supported by research showing that people who are overweight are more likely to develop diabetes, even if they don\u2019t have any other risk factors. Ultimately, more research is needed to determine the exact relationship between brain insulin resistance and diabetes. However, it is clear that both conditions are strongly linked, and that managing one can help to prevent the other.\u201d<\/p>\n
\u2013 Dr. Ahmet Ergin, endocrinologist
\nDr. Kausel described insulin resistance as a \u201cvicious cycle,\u201d noting that the process begins in the liver before it starts affecting different organs, such as the brain.<\/p>\n
\u201cWhen we have brain insulin resistance, the important connection between the brain and gut for hunger [or] satiety signals and metabolism gets impaired, making the problem even worse,\u201d Dr. Kausel said.<\/p>\n
Signs of brain insulin resistance
\nSymptoms of brain insulin resistance to look out for include:
\n\u2022\tchronic fatigue
\n\u2022\tbrain fog
\n\u2022\tlong-term memory problems
\n\u2022\tconstant hunger<\/p>\n
The signs of brain insulin resistance may go unnoticed since these symptoms are also shared by other chronic health conditions.<\/p>\n
\u201cSymptoms of brain insulin resistance include feeling tired after eating, cravings for sugary foods, and difficulty concentrating,\u201d Dr. Ergin said.<\/p>\n
\u201cIn severe cases, brain insulin resistance can lead to weight gain, type 2 diabetes, and other health problems. Because the symptoms of brain insulin resistance are similar to those of other conditions, it can be difficult to diagnose,\u201d he added.
\nRestoring brain insulin sensitivity.<\/p>\n
For people with diagnosed brain insulin resistance or those concerned they might have it based on their symptoms, exercise is linked to improved health in general.<\/p>\n
Making a change away from a sedentary lifestyle is unlikely to cause harm \u2014 but it\u2019s a good idea to speak with your doctor first.<\/p>\n
\u201cI always say to my patients to just start however they can \u2014 that is the first and hardest step,\u201d Dr. Kausel said.<\/p>\n
\u201cMake sure they enjoy the activity so they can sustain it long-term, and every week add 5 minutes to it until they can do it for at least 45 mins.<\/p>\n
The activity doesn\u2019t matter, the point is to move.\u201d
\nDr. Ergin added that exercising to restore insulin sensitivity may feel like a daunting task, which is why it\u2019s important to start slow and set realistic goals.<\/p>\n
\u201cEvery journey begins with a single step,\u201d Dr. Ergin said. \u201cA person might begin by walking for 20 minutes each day and gradually increasing the length and intensity of their workouts over time.\u201d<\/p>\n
Dr. Ergin emphasized exercises that build muscle, such as lifting weights or using resistance bands, which may help improve insulin sensitivity.<\/p>\n
To stay motivated and consistent with your workout routine, Dr. Ergin recommends creating a support system with friends or family members who are also working to improve their health.<\/p>\n
\u201cBy following these simple tips, anyone can begin working toward a healthier lifestyle,\u201d he said.<\/p>\n","protected":false},"excerpt":{"rendered":"
ISLAMABAD, Nov 14 (Online): The link between brain insulin insensitivity and diabetes is well-established, but the exact nature of that connection is still being studied. New research from researchers at the German Center for Diabetes Research, T\u00fcbingen University Hospital, and Helmholtz Munich in Munich, Germany, […]<\/p>\n
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