{"id":116225,"date":"2024-11-05T19:27:10","date_gmt":"2024-11-05T14:27:10","guid":{"rendered":"https:\/\/pni.net.pk\/en\/?p=116225"},"modified":"2024-11-05T16:33:22","modified_gmt":"2024-11-05T11:33:22","slug":"weight-loss-may-help-improve-several-symptoms-of-pcos","status":"publish","type":"post","link":"https:\/\/pni.net.pk\/en\/latest-health-news\/weight-loss-may-help-improve-several-symptoms-of-pcos\/","title":{"rendered":"Weight loss may help improve several symptoms of PCOS"},"content":{"rendered":"<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">ISLAMABAD, NOV 05 (ONLINE): Researchers recently found that weight loss interventions may help those with PCOS reduce weight and improve blood sugar regulation and hormonal markers.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">This work may be the first to uncover a link between weight loss interventions and a clinically significant increase in menstrual frequency.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">The study\u2019s authors suggest that clinicians can consult these findings to advise patients with PCOS regarding weight loss strategies.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">Polycystic ovary syndrome (PCOS), also known as Stein-Leventhal Syndrome, affects women of reproductive age. It is the most common endocrine disorder and cause of infertility among women.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">PCOS has no known cause or cure. Some individuals with PCOS experience few or no symptoms.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">The condition often contributes to irregular or missed ovulation and menstrual periods. It may also lead to abnormally high levels of androgens, which can cause hirsutism.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">Overweight or obesity affects over half of women with PCOS. At least 65% to 80% of people with PCOS live with insulin resistance as well.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">Further, individuals with PCOS and excess weight tend to experience worse medical outcomes than women with PCOS and a healthier weight.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">However, experts at the University of Oxford in the U.K. have found limited evidence that quantifies the effects of weight loss on PCOS symptoms. This paucity has made it difficult for practitioners to recommend specific weight loss strategies for managing PCOS.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">In search of stronger confirmation, the scientists scoured through over 3,000 scientific studies. They also interviewed dozens of women with PCOS.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">Their systematic review suggests that weight loss interventions have fostered \u201cimprovements in some important clinical features of PCOS.\u201d<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">Weight challenges with PCOS<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">According to clinical guidelines in the U.K., 5% weight loss could lower testosterone levels and insulin resistance markers. Health experts recommend offering women with PCOS and overweight advice on lifestyle changes, typically involving weight loss through low-carbohydrate diets and exercise.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">However, this study\u2019s patient and public involvement (PPI) advisors shared that, in their experience, support for weight management was scarce. Evidence also indicates that encouragement for weight loss with no further support is mostly ineffective.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">Medical News Today discussed this study with PCOS expert Dr. Ali Chappell, PhD, MS, RD, founder and CEO of Lilli Health, who was not involved in the review.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">\u201cWhen interventions focus on the root cause of weight gain \u2014 insulin resistance \u2014 PCOS symptoms are more likely to improve. Directly addressing insulin resistance is essential for achieving meaningful improvements in PCOS symptoms, including weight loss,\u201d she explained.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">MNT also discussed this research with Alyssa Pacheco, RD, of The PCOS Nutritionist Alyssa, who was also not involved with the study.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">\u201cPCOS is characterized by hormonal imbalances and metabolic disturbances, [I]nsulin resistance, chronic inflammation, estrogen imbalances, high cortisol, and gut dysbiosis can all make losing weight difficult,\u201d she said.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">Pacheco agreed that weight loss can help improve many PCOS symptoms.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">\u201cWhen someone loses weight, they can usually expect to see improvements in blood sugar and insulin levels, cholesterol levels, and testosterone levels. It also usually means they experience less cravings and fatigue while also having more regular periods.\u201d<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">\u2014 Alyssa Pacheco, RD<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">Pacheco also shared that individuals with PCOS are at a disproportionately higher risk of eating disorders. This, she said, calls for greater caution when discussing weight loss interventions.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">The study\u2019s methods<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">Prior research suggests that low-carbohydrate interventions or pharmacotherapy can promote weight loss and greater improvements in insulin resistance, glucose, and hemoglobin markers than metformin or no intervention.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">However, the University of Oxford team noticed that no reviews had compared \u201cthe full range of weight loss interventions\u201d regarding PCOS management.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">Moreover, previous studies often lacked sufficient data to analyze clinically relevant symptoms and markers for PCOS management, including menstrual frequency, hirsutism, and free androgen index (FAI)Trusted Source.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">The study\u2019s authors searched major medical databases for randomized controlled trials (RCTs) from inception until June 2024. They focused on RCTs of interventions to reduce weight in adults diagnosed with PCOS.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">The experts compared:<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">\u201cusual care\u201d of metformin, oral contraceptives, and standard advice,<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">\u201cminimal intervention\u201d such as advice for losing weight without further support, or<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">placebos.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">They also analyzed trials that compared lower and higher-intensity weight loss interventions.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">Primary outcomes<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">The review\u2019s primary outcomes comprised of symptoms and biological markers of PCOS. They were chosen in consultation with clinicians with expertise in PCOS and 36 individuals with PCOS.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">Included RCTs contained data that allowed weight change calculations and at least one symptom or bio marker of PCOS such as fasting insulin, fasting glucose, testosterone, FAI, menses frequency, acne, and hirsutism.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">The study\u2019s researchers started with 3,760 studies, paring their list down to 39. Over 1,500 people contributed data to the primary analyses, and over 2,300 contributed data to the secondary analyses.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">Improved menstrual frequency after weight loss<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">The University of Oxford team reported: \u201cFor women with PCOS, our systematic review suggests weight loss interventions led to improvements in some important clinical features of PCOS.\u201d<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">They noted decreases in fasting insulin, FAI, and HOMA-IRTrusted Source, an insulin resistance marker, along with increases in menstrual frequency.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">\u201cTo our knowledge, this is the first review to show a clinically significant association in improvement in menstrual frequency with weight loss interventions, an important indicator of subsequent fertility and an important outcome for women,\u201d the team also said.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">However, evidence was inconclusive to establish an association between weight loss interventions and significant changes in fasting glucose, testosterone, hirsutism, and other markers.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">Chappell shared that insulin-lowering methods are most effective in her experience: \u201cSince insulin resistance is at the root of all PCOS symptoms, focusing on lifestyle changes that lower insulin levels helps reverse insulin resistance and leads to weight loss and improvements in other clinical symptoms. I call this a Low Insulin Lifestyle.\u201d<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">\u201cThe most effective weight loss interventions are the ones that focus on treating the underlying root cause of why weight loss is difficult to begin with. I recommend eating balanced meals that include high fiber foods, protein, and healthy fats \u2014 this combination keeps blood sugar levels more stable and reduces cravings throughout the day,\u201d Pacheco told MNT.<\/span><\/p>\n<p class=\"selectable-text copyable-text x15bjb6t x1n2onr6\" dir=\"ltr\"><span class=\"selectable-text copyable-text\">\u201cOther lifestyle factors such as exercise, sleep, and stress can play a big role in insulin resistance and weight loss,\u201d she added.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>ISLAMABAD, NOV 05 (ONLINE): Researchers recently found that weight loss interventions may help those with PCOS reduce weight and improve blood sugar regulation and hormonal markers. This work may be the first to uncover a link between weight loss interventions and a clinically significant increase [&#8230;]<\/p>\n<p>\n","protected":false},"author":2,"featured_media":116226,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9821],"tags":[],"class_list":["post-116225","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-health-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Weight loss may help improve several symptoms of PCOS - Pakistan News International<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pni.net.pk\/en\/latest-health-news\/weight-loss-may-help-improve-several-symptoms-of-pcos\/\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"Weight loss may help improve several symptoms of PCOS - Pakistan News International\" \/>\n<meta name=\"twitter:description\" content=\"ISLAMABAD, NOV 05 (ONLINE): Researchers recently found that weight loss interventions may help those with PCOS reduce weight and improve blood sugar regulation and hormonal markers. 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