{"id":110427,"date":"2024-07-12T00:00:47","date_gmt":"2024-07-11T19:00:47","guid":{"rendered":"https:\/\/pni.net.pk\/en\/?p=110427"},"modified":"2024-07-11T17:11:03","modified_gmt":"2024-07-11T12:11:03","slug":"researchers-successfully-rejuvenate-aging-livers-in-preclinical-study","status":"publish","type":"post","link":"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/","title":{"rendered":"Researchers successfully rejuvenate aging livers in preclinical study"},"content":{"rendered":"<pre class=\"aLF-aPX-K0-aPE\">ISLAMABAD, July 11 (Online): Researchers have been able to reverse age-related damage to liver cells in mice and in human cell cultures in a new study.\r\nThe study homes in on ferroptosis \u2014 a form of iron-dependent cell death \u2014 as an age-related process affecting a set of key cells in the liver, called \u2018hepatocytes.\u2019\r\nIts authors found gene clusters associated with this process in both mice and human cells.\r\nThe takeaway is that it may be possible to reverse aging in affected liver cells through pharmaceutical interventions.\r\nA new study in mice and human cell samples finds that it may be possible to undo some of the damage that occurs with aging, restoring the liver at least partially to health.\r\n\r\nThe authors of the study found an abundance of genes that cause cell death in liver cells from older mice, and in human cells.\r\n\r\nThe age-related genes cause an iron-dependent type of cell death called ferroptosisTrusted Source. Ferroptosis is also implicated in damage to the heart, kidneys, and pancreatic islets.\r\n\r\nThe main focus of the study is nonalcoholic fatty liver disease (NAFLD), also known as \u201cmetabolic dysfunction-associated steatotic liver disease (MASLD)\u201d. It causes cirrhosis, or scarring, of the liver\u2019s main cells, hepatocytes, and can lead eventually to organ failure.\r\n\r\nAfter identifying a cluster of genes that affect the aging of cells in mice, the researchers examined cells collected from humans who had obesity and NAFLD\/ MASLD. They found the same genetic signature, suggesting a target for pharmacological therapy.\r\n\r\nTo confirm their hypothesis, the researchers caused a group of 3-month-old young mice, and one of 2-year-old mice to develop NAFLD\/ MASLD via diet.\r\n\r\nSome of the older mice also received Ferrostatin-1 injections while continuing to be fed the NAFLD\/ MASLD-inducing diet. This was so that the researchers could test the potential therapeutic effects of the drug on aging livers.\r\n\r\nAt the end of the study, the researchers found that liver cells in old mice receiving Ferrostatin-1 appeared young and healthy.\r\n\r\nThe investigators report their study results in the journal Nature AgingTrusted Source.\r\n\r\n\r\nNew therapies to stop liver aging?\r\nThe authors of the new study hope that their findings will lead to therapies for NAFLD\/ MASLD. They also found that \u201cthese genes are similarly upregulated in a variety of human tissues afflicted by disease and aging, including the liver, heart, kidneys, and the pancreatic tissue affected by diabetes,\u201d explained Muhammad Nadeem Aslam, MBBS.\r\n\r\nAslam is an assistant research scientist in the Department of Pathology at the University of Michigan, Ann Arbor, and was not involved in the current study.\r\n\r\n\u201cThis points to the possibility of a shared molecular basis for aging-related tissue degeneration across multiple organ systems,\u201d Aslam said.\r\n\r\nThe study\u2019s senior author, Anna Mae Diehl, MD, the Florence McAlister Distinguished Professor of Medicine at the Duke University School of Medicine, stated in a press release that the \u201cstudy demonstrates that aging is at least partially reversible.\u201d\r\n\r\n\u201cYou are never too old to get better,\u201d said Diehl.\r\n\r\n\u201cWe\u2019ve shown,\u201d she added, \u201cthat aging exacerbates nonalcoholic liver disease by creating ferroptic stress, and by reducing this impact, we can reverse the damage.\u201d\r\n\r\nAslam pointed out that research suggests the molecular underpinnings of ferroptosis have three major aspects: iron metabolism, lipid metabolism, and the antioxidant defense system. \u201cThese pathways offer a variety of potential targets for therapeutic intervention,\u201d he said.\r\n\r\n\u201cThis is hopeful for all of us,\u201d Diehl said in the press release. \u201cIt\u2019s like we had old mice eating hamburgers and fries, and we made their livers like those of young teenagers eating hamburgers and fries.\u201d\r\n\r\n\r\n\u201cThe role of ferroptosis in liver diseases manifests as a double-edged sword. On [the] one hand, inhibiting ferroptosis may mitigate liver injuries and conditions such as fatty liver disease. On the other, inducing ferroptosis can be beneficial by damaging hepatic stellate cells and killing liver cancer cells, thus presenting a potential therapeutic avenue for these afflictions.\u201d\r\n\r\n\r\n\r\n\r\n\u201cHepatocytes, the principal epithelial or parenchymal cells of the liver, account for approximately 80% of the liver\u2019s mass and 70% of its cellular components. They play an indispensable role in metabolism, detoxification, and protein synthesis. The remaining liver structure consists of nonparenchymal cells, including endothelial cells, stellate cells, Kupffer cells, and lymphocytes.\u201d\r\n\r\nNAFLD MASLD has no obvious symptoms beyond fatigue, weakness, or pain and discomfort in the abdomen, and sometimes unexplained weight loss.\r\n\r\n\u201cChildren with [NAFLD\/ MASLD],\u201d reported Aslam, \u201cmay experience symptoms such as abdominal pain, typically centered in or on the upper right part of the abdomen, and fatigue.\u201d However, these may be the result of other issues unrelated to the condition.\r\n\r\n\u201cPhysical examinations [of children] might reveal slight liver enlargement,\u201d said Aslam, \u201cand some children and young adults could have patchy, dark skin discoloration (acanthosis nigricans), usually around the neck and underarms.\u201d\r\n\r\nNAFLD\/ MASLD may be diagnosed in a blood test that shows abnormally high levels of liver enzymes. Blood tests, however, often fail to pick up the condition\u2019s presence.\r\n\r\nAslam said that this liver condition \u201cis frequently discovered incidentally during abdominal imaging procedures, such as ultrasounds or CT scans, that are initially performed for unrelated issues, revealing fatty infiltration of liver cells.\u201d\r\n\r\nThere is no direct treatment for NAFLD\/ MASLD, although maintaining a healthy diet and weight may slow its progression.<\/pre>\n","protected":false},"excerpt":{"rendered":"<p>ISLAMABAD, July 11 (Online): Researchers have been able to reverse age-related damage to liver cells in mice and in human cell cultures in a new study. The study homes in on ferroptosis \u2014 a form of iron-dependent cell death \u2014 as an age-related process affecting [&#8230;]<\/p>\n<p>\n","protected":false},"author":16,"featured_media":110428,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9821],"tags":[],"class_list":["post-110427","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-health-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Researchers successfully rejuvenate aging livers in preclinical study<\/title>\n<meta name=\"description\" content=\"Researchers successfully rejuvenate aging livers in preclinical study\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"Researchers successfully rejuvenate aging livers in preclinical study\" \/>\n<meta name=\"twitter:description\" content=\"Researchers successfully rejuvenate aging livers in preclinical study\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/pni.net.pk\/en\/wp-content\/uploads\/2024\/07\/PNI-Temp-Red-Eng-84.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Tuba Zafar\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/\"},\"author\":{\"name\":\"Tuba Zafar\",\"@id\":\"https:\/\/pni.net.pk\/en\/#\/schema\/person\/0dfa6d46d29e252acc3c6eab88113eff\"},\"headline\":\"Researchers successfully rejuvenate aging livers in preclinical study\",\"datePublished\":\"2024-07-11T19:00:47+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/\"},\"wordCount\":8,\"publisher\":{\"@id\":\"https:\/\/pni.net.pk\/en\/#organization\"},\"image\":{\"@id\":\"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/pni.net.pk\/en\/wp-content\/uploads\/2024\/07\/PNI-Temp-Red-Eng-84.jpg\",\"articleSection\":[\"Health\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/\",\"url\":\"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/\",\"name\":\"Researchers successfully rejuvenate aging livers in preclinical study\",\"isPartOf\":{\"@id\":\"https:\/\/pni.net.pk\/en\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/pni.net.pk\/en\/wp-content\/uploads\/2024\/07\/PNI-Temp-Red-Eng-84.jpg\",\"datePublished\":\"2024-07-11T19:00:47+00:00\",\"description\":\"Researchers successfully rejuvenate aging livers in preclinical study\",\"breadcrumb\":{\"@id\":\"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/#primaryimage\",\"url\":\"https:\/\/pni.net.pk\/en\/wp-content\/uploads\/2024\/07\/PNI-Temp-Red-Eng-84.jpg\",\"contentUrl\":\"https:\/\/pni.net.pk\/en\/wp-content\/uploads\/2024\/07\/PNI-Temp-Red-Eng-84.jpg\",\"width\":660,\"height\":360},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/pni.net.pk\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Researchers successfully rejuvenate aging livers in preclinical study\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/pni.net.pk\/en\/#website\",\"url\":\"https:\/\/pni.net.pk\/en\/\",\"name\":\"Pakistan News International\",\"description\":\"Latest News, Breaking News from Pakistan\",\"publisher\":{\"@id\":\"https:\/\/pni.net.pk\/en\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/pni.net.pk\/en\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/pni.net.pk\/en\/#organization\",\"name\":\"Pakistan News International\",\"url\":\"https:\/\/pni.net.pk\/en\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/pni.net.pk\/en\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/pni.net.pk\/en\/wp-content\/uploads\/2021\/12\/site-logo.jpg\",\"contentUrl\":\"https:\/\/pni.net.pk\/en\/wp-content\/uploads\/2021\/12\/site-logo.jpg\",\"width\":431,\"height\":121,\"caption\":\"Pakistan News International\"},\"image\":{\"@id\":\"https:\/\/pni.net.pk\/en\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/pni.net.pk\/en\/#\/schema\/person\/0dfa6d46d29e252acc3c6eab88113eff\",\"name\":\"Tuba Zafar\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/pni.net.pk\/en\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/744ef34d1951e7021517824208536635504a982cfd8baa76dc349d66268b2063?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/744ef34d1951e7021517824208536635504a982cfd8baa76dc349d66268b2063?s=96&d=mm&r=g\",\"caption\":\"Tuba Zafar\"},\"sameAs\":[\"http:\/\/pni.net.pk\"],\"url\":\"https:\/\/pni.net.pk\/en\/author\/tuba\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Researchers successfully rejuvenate aging livers in preclinical study","description":"Researchers successfully rejuvenate aging livers in preclinical study","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/","twitter_card":"summary_large_image","twitter_title":"Researchers successfully rejuvenate aging livers in preclinical study","twitter_description":"Researchers successfully rejuvenate aging livers in preclinical study","twitter_image":"https:\/\/pni.net.pk\/en\/wp-content\/uploads\/2024\/07\/PNI-Temp-Red-Eng-84.jpg","twitter_misc":{"Written by":"Tuba Zafar","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/#article","isPartOf":{"@id":"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/"},"author":{"name":"Tuba Zafar","@id":"https:\/\/pni.net.pk\/en\/#\/schema\/person\/0dfa6d46d29e252acc3c6eab88113eff"},"headline":"Researchers successfully rejuvenate aging livers in preclinical study","datePublished":"2024-07-11T19:00:47+00:00","mainEntityOfPage":{"@id":"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/"},"wordCount":8,"publisher":{"@id":"https:\/\/pni.net.pk\/en\/#organization"},"image":{"@id":"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/#primaryimage"},"thumbnailUrl":"https:\/\/pni.net.pk\/en\/wp-content\/uploads\/2024\/07\/PNI-Temp-Red-Eng-84.jpg","articleSection":["Health"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/","url":"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/","name":"Researchers successfully rejuvenate aging livers in preclinical study","isPartOf":{"@id":"https:\/\/pni.net.pk\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/#primaryimage"},"image":{"@id":"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/#primaryimage"},"thumbnailUrl":"https:\/\/pni.net.pk\/en\/wp-content\/uploads\/2024\/07\/PNI-Temp-Red-Eng-84.jpg","datePublished":"2024-07-11T19:00:47+00:00","description":"Researchers successfully rejuvenate aging livers in preclinical study","breadcrumb":{"@id":"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/#primaryimage","url":"https:\/\/pni.net.pk\/en\/wp-content\/uploads\/2024\/07\/PNI-Temp-Red-Eng-84.jpg","contentUrl":"https:\/\/pni.net.pk\/en\/wp-content\/uploads\/2024\/07\/PNI-Temp-Red-Eng-84.jpg","width":660,"height":360},{"@type":"BreadcrumbList","@id":"https:\/\/pni.net.pk\/en\/latest-health-news\/researchers-successfully-rejuvenate-aging-livers-in-preclinical-study\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/pni.net.pk\/en\/"},{"@type":"ListItem","position":2,"name":"Researchers successfully rejuvenate aging livers in preclinical study"}]},{"@type":"WebSite","@id":"https:\/\/pni.net.pk\/en\/#website","url":"https:\/\/pni.net.pk\/en\/","name":"Pakistan News International","description":"Latest News, Breaking News from Pakistan","publisher":{"@id":"https:\/\/pni.net.pk\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/pni.net.pk\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/pni.net.pk\/en\/#organization","name":"Pakistan News International","url":"https:\/\/pni.net.pk\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/pni.net.pk\/en\/#\/schema\/logo\/image\/","url":"https:\/\/pni.net.pk\/en\/wp-content\/uploads\/2021\/12\/site-logo.jpg","contentUrl":"https:\/\/pni.net.pk\/en\/wp-content\/uploads\/2021\/12\/site-logo.jpg","width":431,"height":121,"caption":"Pakistan News International"},"image":{"@id":"https:\/\/pni.net.pk\/en\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/pni.net.pk\/en\/#\/schema\/person\/0dfa6d46d29e252acc3c6eab88113eff","name":"Tuba Zafar","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/pni.net.pk\/en\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/744ef34d1951e7021517824208536635504a982cfd8baa76dc349d66268b2063?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/744ef34d1951e7021517824208536635504a982cfd8baa76dc349d66268b2063?s=96&d=mm&r=g","caption":"Tuba Zafar"},"sameAs":["http:\/\/pni.net.pk"],"url":"https:\/\/pni.net.pk\/en\/author\/tuba\/"}]}},"_links":{"self":[{"href":"https:\/\/pni.net.pk\/en\/wp-json\/wp\/v2\/posts\/110427","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/pni.net.pk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/pni.net.pk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/pni.net.pk\/en\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/pni.net.pk\/en\/wp-json\/wp\/v2\/comments?post=110427"}],"version-history":[{"count":1,"href":"https:\/\/pni.net.pk\/en\/wp-json\/wp\/v2\/posts\/110427\/revisions"}],"predecessor-version":[{"id":110429,"href":"https:\/\/pni.net.pk\/en\/wp-json\/wp\/v2\/posts\/110427\/revisions\/110429"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/pni.net.pk\/en\/wp-json\/wp\/v2\/media\/110428"}],"wp:attachment":[{"href":"https:\/\/pni.net.pk\/en\/wp-json\/wp\/v2\/media?parent=110427"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/pni.net.pk\/en\/wp-json\/wp\/v2\/categories?post=110427"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/pni.net.pk\/en\/wp-json\/wp\/v2\/tags?post=110427"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}