ISLAMABAD, April 18 (Online): Medications that help control high blood pressure may offer a new strategy for the prevention of uterine fibroids.ResearchTrusted Source published in the journal JAMA Network Open reports that women in midlife with untreated or new onset hypertension have an increased risk of fibroids while those who are on antihypertensive treatments for blood pressure have a lower risk.
\n\u201cInvestigation into mechanisms and health implications is warranted; if the associations are causal, antihypertensive medication use where indicated may present an opportunity to prevent clinically apparent fibroid development at this high-risk life stage,\u201d the study authors wrote.<\/p>\n
Nearly 120 millionTrusted Source adults in the United States have high blood pressure, also called hypertension. About 44%Trusted Source of them are women.
\nHigh blood pressure can create health issues for the heart as well as the eyes, kidneys, and brain.
\nUterine fibroids and high blood pressure
\nA growing body of research also suggests an association between high blood pressure and uterine fibroids, a type of muscular tumor that grows in the walls of the uterus.<\/p>\n
\u201cSeveral prospective studies have now shown that elevated blood pressure associates with the presence of uterine fibroids. While this does not prove causation per se, and residual confounding is always possible, this has been a robust association across multiple patient cohorts spanning women of different age ranges. One of the most interesting new findings in this study is that treatment with antihypertensive medications lowered the risk of a self-reported diagnosis of uterine fibroids,\u201d said Dr Vivek Bhalla, an associate professor of medicine specializing in hypertension at Stanford University in California who was not involved in the study.
\n\u201cBased on both clinical and basic research findings, there has been a suggestion that causes of elevated blood pressure (eg activation of the renin-angiotensin system) may contribute to uterine smooth muscle cell injury and, therefore, the development of fibroids,\u201d Bhalla told Medical News Today. \u201cElevated blood pressure itself, either via atherosclerosis or shear stress or both, may also contribute. On the other hand, the presence of uterine fibroids may also raise blood pressure. Therefore, the relationship may be bidirectional but prospective studies suggest that hypertension may at least cause fibroids.\u201d
\nBetween 20% and 80%Trusted Source of women develop uterine fibroids by the time they are 50. They are most common in women in their 40s and early 50s.<\/p>\n
Research suggests there are some similarities between fibroids and hypertension. Both are common, both are associated with morbidity, both involve changes to smooth muscle cells, and both are more common in people of African descent.
\nFibroids don\u2019t always cause symptoms, but if symptoms do occur they can be challenging and include pain, heavy menstrual bleeding, frequent urination, and pressure in the rectum.<\/p>\n
High blood pressure medications may lower fibroid risk
\nResearch suggests that hypertension is a consistently identified risk factor for fibroids.
\n\u201cFibroids are one aspect of a list of different reasons as to why being aware of your blood pressure status, as well as treating it, is going to be critically important. We\u2019re starting to understand that the blood pressure in different organ systems is as important as your heart,\u201d Dr. Nicole Weinberg, a cardiologist at Providence Saint John\u2019s Health Center in California who was not involved in the study, told Medical News Today.<\/p>\n
The new research suggests that some blood pressure medications may have an impact in preventing fibroids from developing.
\n\u201cAntihypertensive medications can lower blood pressure and possibly the risk of atherosclerosis and\/or smooth muscle injury of the arteries that provide blood flow to the uterus. There are also classes of antihypertensive medications, ie inhibitors of the renin-angiotensin system, that may have a direct effect. In this study, these inhibitors were associated with the largest risk reduction,\u201d Bhalla said.<\/p>\n
However, the new research does not determine how exactly blood pressure medications might work to prevent fibroids from occurring.
\nSome experts argue more research is needed before these findings can have clinical relevance.
\n\u201cThe study does not really describe or postulate how anti-hypertensive medications might prevent the development of uterine fibroids. The mechanism of action of all of these anti-hypertensives are different. They just note that there is a correlation or association between being treated for hypertension and incidence of uterine fibroids,\u201d said Dr. G. Thomas Ruiz, the lead OB\/GYN at MemorialCare Orange Coast Medical Center in California who was not involved in the study.<\/p>\n
Hypertension needs to be well managed
\nDr. Parveen Garg, a cardiologist at Keck Medicine of USC in California who was not involved in the study, says while more research is needed, this study is an important reminder that hypertension should be taken seriously.
\n\u201cWe already know that high blood pressure, if it\u2019s untreated, leads to pretty disastrous consequences all throughout the body. But this basically just reinforces that we need to take high blood pressure seriously and we need to treat it when we recognize it,\u201d he told Medical News Today.<\/p>\n
\u201cIn general, we know that hypertension causes much more serious comorbidities. Heart failure, stroke, heart disease, kidney failure. If left untreated, it leads to some really serious comorbidities that can be life threatening,\u201d Garg added.
\nRegardless of whether or not medications for high blood pressure help prevent fibroids, experts say it is essential the people with hypertension take steps to manage their condition.
\n\u201cWith any patient with hypertension, especially for patients at high cardiovascular risk, vigilant attention to diet and lifestyle changes and as needed for persistently elevated blood pressure, antihypertensive medications, lower overall cardiovascular risk,\u201d Bhalla said. \u201cWhether treatment with medication lowers the risk of the development of fibroids will require additional studies. This paper is an intriguing step in that direction.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"
ISLAMABAD, April 18 (Online): Medications that help control high blood pressure may offer a new strategy for the prevention of uterine fibroids.ResearchTrusted Source published in the journal JAMA Network Open reports that women in midlife with untreated or new onset hypertension have an increased risk […]<\/p>\n
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