ISLAMABAD, MARCH 21 (ONLINE): About 1.8 million deaths each year are attributable to lung cancer, making it the leading cause of cancer death around the world.
\nOnly 16% of people with lung cancer receive an early diagnosis, which offers a much higher survival rate.<\/p>\n
Researchers say they have developed a new way to detect lung cancer at its earliest stages using an inhaler and a simple urine test.
\nAbout 1.8 million deathsTrusted Source each year are attributable to lung cancer, making it the leading cause of cancer death globally.<\/p>\n
Previous research reports that only 16% of peopleTrusted Source receive a lung cancer diagnosis at an early stage.<\/p>\n
However, as with any type of cancer, an early diagnosisTrusted Source of lung cancer offers better outcomes. Studies show that the average 5-year lung cancer survival rateTrusted Source in the U.S. is as low as 18%, but that rate jumps as high as 55% when caught at an early stage.<\/p>\n
Now, researchers from the Massachusetts Institute of Technology (MIT) say they have developed a new way to detect lung cancer at its earliest stages using an inhaler and a simple urine test.<\/p>\n
The study was recently published in the journal Science Advances.<\/p>\n
Why is lung cancer hard to detect early?
\nCurrent guidelines recommend anyone between the ages of 55 and 80 years old who has a history of heavy smoking should be screened for lung cancer.<\/p>\n
Right now, the gold standard for lung cancer screening is the low-dose computed tomography (CT) scan. However, CT scans can sometimes produce falseTrusted Source positives or negatives.<\/p>\n
Past research shows that the majorityTrusted Source of lung cancer cases are diagnosed at an advanced stage because most people do not have any symptoms in the earliest stages.<\/p>\n
\u201cLung cancer is such a difficult diagnosis for many patients because it doesn\u2019t give us many warning signs before it\u2019s at an advanced stage,\u201d explained Dr. Michael Spallone, a thoracic surgeon with Hackensack University Medical Center in New Jersey who was not involved in this study. \u201cIn fact, many of the lung cancers we diagnose on a day-to-day basis is based off of incidental findings; in other words, the patient has had imaging done for another reason, i.e. chest pain or cough, that just so happened to pick up an unrelated finding of a lung nodule or mass.\u201d<\/p>\n
\u201cMany lung cancers can be cured if detected early, particularly with surgical resectionTrusted Source,\u201d Spallone told Medical News Today. \u201cHowever, surgery is an available option only before the cancer has spread or become too invasive to resect. Therefore, anything that gives us an earlier warning that something may be going on, is an advantage to us and patients alike.\u201d<\/p>\n
Lung cancer screening in 20 minutes
\nFor this study, researchers used a new technology using nanoparticleTrusted Source sensors that are breathed in through the use of an inhaler or nebulizer.<\/p>\n
The nanoparticle sensors are coated with a reporter, such as a DNA barcode, making them into \u201cnano-detectives\u201d for lung cancer screening, said Qian Zhong, a research scientist at MIT and co-lead author of this study.<\/p>\n
\u201cUpon inhalation, these DNA-barcoded nanoparticles patrol the lungs in search of cancer-associated proteaseTrusted Source signatures,\u201d Zhong told Medical News Today. \u201cThe nanoparticles are engineered to be activated by disease signals in the tumor microenvironment, releasing the DNA barcodes into the bloodstream, which are then filtered into the urine.\u201d<\/p>\n
\u201cWe analyze these urinary \u2018fingerprints\u2019 using a multiplexed quantitative lateral flow assay,\u201d he added. \u201cResults can be obtained at room temperature from the paper test within 20 minutes.\u201d<\/p>\n
Could new lung cancer inhaler test replace CT scans?
\nAs access to CT scans is limited in certain parts of the world, scientists believe this inhaler screening test may provide another option.<\/p>\n
\u201cCT remains one of the best imaging modalities with high resolution to visualize malignant nodules when substantial respiratory symptoms associated with lung cancer have been spotted or developed,\u201d Dr. Edward Tan, a former postdoctoral research fellow at MIT and co-lead author of this study, explained to Medical News Today. \u201cHowever, up to 95 percent of CT-positive patients are false positive. For those early nodules that cannot be confirmed benign or malignant in a single visit or are located in deep lung areas, one or more CT scans in (the) following months or years are needed for confirmation. Unfortunately, many patients in reality don\u2019t follow the recommendations or miss the follow-up appointments.\u201d<\/p>\n
\u201cThe whole process is costly and always completed in several visits, which is definitely [a burden] to low-income households which live pay check by pay check,\u201d Tan added. \u201cTherefore, many at-risk people from low-income households have limited\/no access to this lung cancer program even in the U.S., not to mention in other low-income countries. So we believe that the accessibility to this kind of screening could have a big impact in those contexts.\u201d<\/p>\n
Future lung cancer research steps
\nThis new lung cancer screening test was tested on a mouse model during this study. The mice were genetically engineered to develop lung tumors similar to those seen in humans.<\/p>\n
Through various experiments, scientists measured the levels of 20 different sensors, ultimately identifying four required sensors for diagnostic results. These four sensors were tested again in the mouse model and researchers reported it could accurately detect early-stage lung cancer tumors.<\/p>\n
The research team reportedly plans to next test the sensors on human biopsy samples and eventually perform clinical trials on humans.<\/p>\n
\u201cWe are actively exploring the platform\u2019s utility for detecting other pulmonary diseases, such as infections,\u201d Tan said. \u201cAnother exciting application of the PATROL platform is therapeutic monitoring. For instance, it could serve as a tool to assess patients\u2019 responses to specific treatments. Regarding translation to clinical use, further optimization of the nanosensor probes and extensive preclinical studies are required.\u201d<\/p>\n
\u2018Exciting\u2019 technology and innovation in lung cancer diagnosis
\nAfter reviewing this study, Spallone told MNT that this type of technology and innovation is so exciting to see.<\/p>\n
\u201cIt\u2019s part of the reason that many of us choose to go into medicine in the first place,\u201d he said. \u201cMedicine is constantly changing, adapting, and improving. In the cancer world, particularly lung cancer, the name of the game is early detection. Anything that gets us an earlier diagnosis has the potential to improve outcomes for patients.\u201d<\/p>\n
\u201cThe other aspect that I love is the ease of the proposed test,\u201d Spallone added. \u201cMany patients are familiar with using an inhaler and a urine test is one of simplest diagnostic tools available for patients. It doesn\u2019t involve needles or radiation such as an X-ray or CT scan. Any time you can simplify testing and make it safe, patients tend to be more comfortable taking advantage of it.\u201d<\/p>\n
Spallone commented that the obvious next step for this type of research is to test its effectiveness in humans.<\/p>\n
\u201cThe article highlights the fact that human lung cancer is more complicated than the mouse models it was initially tested on,\u201d he explained. \u201cYou want to make sure the test is sensitive \u2014 it knows when cancer is there \u2014 and you want it to be specific \u2014 it knows that it\u2019s cancer and not something else. This often takes time and meticulous effort on the part of the research team. That being said, I have a lot of optimism that it could become a more attractive and available option to those appropriate for lung cancer screening in (the) future.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"
ISLAMABAD, MARCH 21 (ONLINE): About 1.8 million deaths each year are attributable to lung cancer, making it the leading cause of cancer death around the world. Only 16% of people with lung cancer receive an early diagnosis, which offers a much higher survival rate. Researchers […]<\/p>\n
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