ISLAMABAD, MARCH 06 (ONLINE): Cognitive and memory impairment can occur in people after infection with SARS-CoV-2, the virus that causes COVID-19, and this effect is greater in people with long COVID.
\nThose who received at least two vaccinations and had fewer repeat infections, and those who were infected with later variants of SARS-CoV-2 had lower measures of cognitive decline.<\/p>\n
There are still a number of questions remaining about \u2018brain fog\u2019 in people who have long COVID.
\nPeople who had an infection with SARS-CoV-2, the virus that causes COVID-19, showed measurable cognitive impairment compared with those who have not had COVID-19, a new study from Imperial College of London in the United Kingdom shows.<\/p>\n
While the cognitive and memory deficits were small for people who had mild infections or did not go on to develop long COVID, the effect of more severe infections that resulted in admission to intensive care units was associated with a more pronounced effect.
\nThe researchers found that vaccination had a protective effect, however.<\/p>\n
The study, published in The New England Journal of Medicine, used a multiple regression analysis to focus on the results of 112,964 adults in England.\u2018First accurate quantification\u2019 of cognitive impact of COVID-19
\nStudy participants who had recovered from COVID-19 and whose symptoms resolved in less than 4 weeks or at least 12 weeks had small cognitive deficits compared with those in the \u201cno\u2013COVID-19 group,\u201d who had not ever been infected with the SARS-CoV-2 virus, or had unconfirmed infection.<\/p>\n
People who had symptoms occurring over 12 weeks after recovery from the initial infection \u2014 such as chronic fatigue, respiratory difficulty, or neurological issues \u2014 had greater cognitive deficits, as did people who had become infected with early variants of the SARS-CoV-2 virus.Even though the researchers did not attach a \u201clong COVID\u201d diagnosis to these participants, such persistent symptoms are common in people with this post-viral condition.<\/p>\n
\u201cBy using an innovative cognitive test which has also been completed by people who did not have COVID-19, this important and well-conducted study provides the first accurate quantification of the scale of cognitive deficits in people who had COVID-19,\u201d Dr. Maxime Taquet, NIHR Academic Clinical Fellow in Psychiatry, University of Oxford, who was not involved with the study, commented.<\/p>\n
Dr. Taquet added that the disparity was the most obvious at the extremes:<\/p>\n
\u201cThe risk of having more severe cognitive problems was almost twice as high in those who had COVID-19 compared to those who did not, and three times as high in those who were hospitalised with COVID-19. A few key questions remain open: Do these cognitive problems persist or improve in the years after infection? What is their biological explanation? How does it affect people\u2019s everyday life and their ability to work?\u201d<\/p>\n
How does COVID-19 affect cognitive development, memory?
\nThe mental and psychological effects of COVID-19 have been the focus of study since evidence emerged they were linked to SARS-CoV-2 infections in 2020.<\/p>\n
Long COVID has been associated with longer periods of anxiety, poor memory, or struggles with concentration or thinking, but this study did not draw any significant conclusions about the neurocognitive impact of long COVID.<\/p>\n
The authors emphasize that further study is required here.<\/p>\n
\u201cWe focused on symptoms that had persisted for at least 12 weeks, and we did not depend on a diagnosis of long Covid, which may require clinical assessment,\u201d the study authors wrote. \u201cIn the absence of baseline cognitive data before infection, we could not assess cognitive change, and the observational nature of the data means that we could not infer causality.\u201d<\/p>\n
Dr. Scott Kaiser, MD, a board-certified geriatrician and director of Geriatric Cognitive Health for the Pacific Neuroscience Institute at Providence Saint John\u2019s Health Center in Santa Monica, CA, who was not involved in the study, told Medical News Today that it helps fill out some of the ongoing uncertainty around \u201cbrain fog.\u201d<\/p>\n
\u201cThis study reinforces the idea that the experience of cognitive impairment following COVID is quite frequent and is striking in the extent to which this impairment may persists for many months following infection, even in cases that were not that severe,\u201d Dr. Kaiser said.<\/p>\n
\u201cAs far as the true long-term consequences it\u2019s just too soon to tell. While it appears that most cases gradually resolve \u2014 even if it takes several months \u2014 it\u2019s unclear if a subset of people may continue to have lingering symptoms across an even longer time horizon. Similarly, it remains unknown whether this could actually increase one\u2019s ultimate risk of a major neurocognitive disorder \u2014 dementia \u2014 later in life.\u201d<\/p>\n
\u2013 Dr. Scott Kaiser<\/p>\n
Who is at greatest risk of cognitive impairment after COVID-19?
\nThe study found that participants who had received two or more vaccinations and had minimal repeat infections of COVID-19 had less cognitive decline.<\/p>\n
Similarly, those who were infected with later variants of SARS-CoV-2 had better cognitive abilities than those who were infected during the alpha stage of the pandemic.<\/p>\n
The authors of the study also note that the delta variant occurred in \u201ca highly vaccinated population.\u201d<\/p>\n
Dr. Kaiser advised that anyone experiencing brain fog should reach out to a medical professional and seek guidance, given that at this stage in the pandemic there are more resources available and better opportunities to understand what long-term effects the SARS-CoV-2 virus has on cognition.<\/p>\n
\u201cBecause this is all a relatively new phenomena the overall understanding continues to evolve. There are many potential pathways \u2014 reduced oxygen delivery, reduced blood flow, an attack by the immune system on healthy brain cells or an actual invasion of infectious cells into the brain, or inflammation affecting brain cells \u2014 and a combination of multiple factors may be at play,\u201d Dr. Kaiser said.<\/p>\n
\u201cAdditional factors associated with having COVID may indirectly contribute as well \u2014 increased stress and anxiety, depressed mood, changes in diet, medications, decreased physical activity, poor sleep quality, or even social isolation and feelings of loneliness,\u201d he added.<\/p>\n
\u201dAnd while it\u2019s possible that certain cases have very different causes, overall, there does appear to be a clear physiologic pathway by which infection with the virus induces an inflammatory response which actually causes inflammation in the brain \u2014 neuroinflammation \u2014 which can, in turn, can cause cognitive dysfunction.\u201d<\/p>\n
\u2013 Dr. Scott Kaiser<\/p>\n
What have we learned about brain fog in long COVID so far?
\nThe peak of the COVID-19 pandemic may be behind us, but for many people, long COVID continues to cause symptoms weeks, months, or even years after the initial illness. Among the more than 200 symptoms reported for long COVID, brain fog \u2014 problems with thinking, understanding, focus and memory \u2014 is one of the most widespread and long-lasting.<\/p>\n","protected":false},"excerpt":{"rendered":"
ISLAMABAD, MARCH 06 (ONLINE): Cognitive and memory impairment can occur in people after infection with SARS-CoV-2, the virus that causes COVID-19, and this effect is greater in people with long COVID. Those who received at least two vaccinations and had fewer repeat infections, and those […]<\/p>\n
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