ISLAMABAD, Jan 20 (Online): As we get older, our body \u2014 including our brain \u2014 naturally begins to age. Certain tasks that the brain performs, such as memory and learningTrusted Source, begin to decline.
\nAccording to the National Institute on AgingTrusted Source, previous research shows that living a healthy lifestyle that includes physical activity, stress management, fostering social connections, and eating right, can help slow brain aging.<\/p>\n
Now researchers from the Buck Institute for Research on Aging in Novato, CA, have found that restricting the amount of food a person eats may also help protect the brain from aging, via models of both fruit flies and human cells.
\nThe research \u2014 recently published in the journal Nature CommunicationsTrusted Source \u2014 identified a specific gene that is enhanced through calorie restriction, aiding processes necessary for healthy brain aging.<\/p>\n
How calorie restriction affects brain aging
\nAccording to Dr. Lisa Ellerby, professor at the Buck Institute for Research on Aging, adjunct professor of gerontology at the USC Leonard Davis School of Gerontology, and co-senior author of this study, the team decided to study the impact of calorie restriction on brain aging because dietary restriction is a significant intervention for the aging process and the brain is a particularly vulnerable organ during aging.<\/p>\n
\u201cTherefore, understanding factors that are modulated by dietary restriction and are protective in the brain is a significant research direction in the field,\u201d Dr. Ellerby told Medical News Today. \u201cPlus, many people are doing various forms of caloric restriction, in particular, intermittent fasting. This was a beginning step in understanding how those efforts might impact brain aging.\u201d
\nFor example, a review of research published in February 2021 reported that dietary restriction may help protect the brain against neuroinflammation and neurodegenerationTrusted Source.
\n\u201cAge-related disease is arguably the greatest biomedical challenge in the 21st century,\u201d Dr. Ellerby said.
\n\u201cAge is the largest risk factor for developing diseases of the brain. Postponing or decreasing the rate of aging could retard multiple age-related diseases and thus neurological diseases. In terms of Alzheimer\u2019s and Parkinson\u2019s disease, there are no available treatments to actually treat the diseases, so it\u2019s important that we understand ways to prevent or slow the progression of neurodegenerative diseases.\u201d<\/p>\n
\u2013 Dr. Lisa Ellerby
\nIdentifying the gene affected by calorie restriction
\nFor this study, Dr. Ellerby and her team used both fruit fly models and human cells to examine how calorie restriction might affect how the brain ages.
\nThe team used a fruit fly model of 160 different fly strains with different genetic backgrounds. Flies were either raised on a normal diet or a diet that was only 10% of its normal nutrition.
\nFrom there, researchers identified five genes that had specific variants that significantly impacted longevity under dietary restriction.
\nOne of those is the \u201cmustard\u201d gene in fruit flies that correlates to the oxidation resistance 1 (OXR1) geneTrusted Source in humans and rodents.<\/p>\n
Previous research shows that a depletionTrusted Source of OXR1 gene products is a shared feature of neurodegenerative conditions like Parkinson\u2019s disease and diabetic retinopathy, while studies in mice show that overexpression of OXR1 may be protectiveTrusted Source against amyotrophic lateral sclerosis (ALS).
\nThe role of protein \u2018recycling\u2019 in aging
\nAdditionally, scientists found the OXR1 gene affects the retromerTrusted Source, which sorts proteins and decides which can be reused by the body and which cannot.<\/p>\n
\u201cRecycling is important in our daily life,\u201d Dr. Ellerby explained. \u201cA cell does a similar process \u2014 it needs to recycle damaged components. The retromer is a cellular complex known to recycle proteins and lipids.\u201d
\n\u201cIt was surprising [that] a protein known as OXR1 [expressed by the OXR1 gene] is involved in the retromer function,\u201d she continued. \u201cIn past research, this protein was thought to be involved in responding to oxidative stressTrusted Source or detoxification.\u201d
\nDr. Ellerby said she and her colleagues believe these findings may be used in the future to help identify potential therapeutic targets to potentially slow aging and age-related neurodegenerative diseases.<\/p>\n
\u201cFinding factors that make the brain resilient or prevent the aging process will be important to slowing aging,\u201d she continued. \u201cIt is possible that simple changes in our diet can increase the levels of OXR1 in the brain and this would be protective.\u201d
\n\u201cWe boosted OXR1 in the flies via genetic manipulation,\u201d Dr. Ellerby added. \u201cWe are planning to identify small molecules that increase the expression of OXR1 to design a therapeutic for the aging brain.\u201d<\/p>\n
Further studies should assess link between diet and brain aging
\nMNT also spoke with Dr. Clifford Segil, a neurologist at Providence Saint John\u2019s Health Center in Santa Monica, CA, about this study.
\nAfter reading this research, Dr. Segil commented that it remains challenging to elucidate which findings can translate into providing neurologists with something to advise their patients to do to promote healthy eating.
\n\u201cDietary restriction was noted to have clear mechanisms of action with enhanced metabolism and fat burning with age and dietary restriction in the brain is something that should be pursued in more complicated organisms than fruit flies and yeast, though the research has to start in these simple organisms,\u201d he explained.<\/p>\n
\u201cDietary and caloric restriction, I believe, are worthy of further studies to determine if our excessive cultural caloric intake provides us with more harm than benefits. A healthy diet decreases the [chances] of having a stroke or cerebrovascular disease also,\u201d added Dr. Segil.
\nHe further pointed out that, with the current trend of injectable medications being used on a widespread basis for weight loss, large numbers of people are going to be effectively diet-restricted.<\/p>\n","protected":false},"excerpt":{"rendered":"
ISLAMABAD, Jan 20 (Online): As we get older, our body \u2014 including our brain \u2014 naturally begins to age. Certain tasks that the brain performs, such as memory and learningTrusted Source, begin to decline. According to the National Institute on AgingTrusted Source, previous research shows […]<\/p>\n
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